Antibacterial
Types
B-lactams (Interfere with bacterial cell wall peptidoglycan synthesis by binding to penicillin-binding proteins > cell lysis)
- Carbapenems
- Cephalosporins
- Penicillins
B-Lactamases (inhibit B-lactamase to allow b-lactam activity)
Glycopeptides (inhibit bacterial cell wall synthesis by preventing formation of peptidoglycan polymers)
Aminoglycosides (Inhibit protein synthesis by irreversibly binding to the 30S ribosomal subunit and causing cell membrane damage)
Lincosamides (inhibit protein synthesis by binding to the 50S ribosomal subunit) STATIC not CIDAL
Macrolides (inhibit protein synthesis by binding to the 50S ribosomal subunit) STATIC not CIDAL
Tetracyclines (inhibit protein synthesis by reversibly binding to 30S subunit of the ribosome) STATIC not CIDAL
Nitroimidazoles (thought to interfere with DNA synthesis)
Quinolones (inhibit DNA synthesis by blocking DNA gyrase and topoisomerase IV)
Rifamycins (inhibit RNA polymerase)
Antimycobacterials
Other antibacterials
- Monobactam (Aztreonam)
---------------------------------
Gm Pos v Neg cover
Anaerobic cover: carbapenems, penicillin + b-lactamase, metronidazole