Cytochrome P450
are hemoprotein enzymes, usually the terminal oxidase enzyme in an electron transport chain
Inducers
1A2
15% of liver cytochromes
Stimulated by aromatic carbon in tobacco but not nicotine
Causes lower serum levels of drugs, therefore toxicity may occur with cessation
Warfarin, Theophylline, chlorpromazine, clozapine, olanzapine, insulin
Melatonin, benzos, fluphenazine, haloperidol, TCA, fluvoxamine, sulphonylureas, dulozetine, mirtazapine, carbamazepine
Inducers
1A2
15% of liver cytochromes
Stimulated by aromatic carbon in tobacco but not nicotine
Causes lower serum levels of drugs, therefore toxicity may occur with cessation
Warfarin, Theophylline, chlorpromazine, clozapine, olanzapine, insulin
Melatonin, benzos, fluphenazine, haloperidol, TCA, fluvoxamine, sulphonylureas, dulozetine, mirtazapine, carbamazepine