Interferon
Cytokine
Interferon alfa: Suppresses cell proliferation, enhances phagocytosis by macrophages, augmenting cytotoxicity of lymphocytes
> alpha 2a: renal cell carcinoma, mycosis fungoides, Sezary syndrome, myeloproliferative disorders, hepatitis B, hepatitis C
> alpha 2b: Hairy cell leukaemia, Kaposi's sarcoma in AIDS, Chronic myelogenous leukaemia, Multiple myeloma, Follicular non-Hodgkin's lymphoma, Malignant melanoma, Chronic hepatitis B, Chronic hepatitis C.
>alpha ?2a or b: hep C associated cryoglobinaemia, behçet
Interferon beta: antagonism of gamma interferon, reduction of cytokine release, augmentation of suppressor T cell function
> Multiple Sclerosis (beta-1a, 1b)
Interferon gamma 1b: Stimulates macrophage function
> protection from infection in chronic granulomatous disease
PEG (Polyethylene glycol): pegylation increases half life ie slows SC absorption, slows elimination, and reduces immunogenicity
Haemangioma (no longer used due to S.E.)
Adverse effects: spastic diplegia
Interferon alfa: Suppresses cell proliferation, enhances phagocytosis by macrophages, augmenting cytotoxicity of lymphocytes
> alpha 2a: renal cell carcinoma, mycosis fungoides, Sezary syndrome, myeloproliferative disorders, hepatitis B, hepatitis C
> alpha 2b: Hairy cell leukaemia, Kaposi's sarcoma in AIDS, Chronic myelogenous leukaemia, Multiple myeloma, Follicular non-Hodgkin's lymphoma, Malignant melanoma, Chronic hepatitis B, Chronic hepatitis C.
>alpha ?2a or b: hep C associated cryoglobinaemia, behçet
Interferon beta: antagonism of gamma interferon, reduction of cytokine release, augmentation of suppressor T cell function
> Multiple Sclerosis (beta-1a, 1b)
Interferon gamma 1b: Stimulates macrophage function
> protection from infection in chronic granulomatous disease
PEG (Polyethylene glycol): pegylation increases half life ie slows SC absorption, slows elimination, and reduces immunogenicity
Haemangioma (no longer used due to S.E.)
Adverse effects: spastic diplegia