Thrombophilia
Clotting tendency
Investigate if non CVC or recurrent
Thrombus
Inherited (prevalence)
Acquired
Investigate if non CVC or recurrent
Thrombus
- DVT
- PE
- Stroke
Inherited (prevalence)
- Factor V Leiden mutation (12%) (mutation in factor V preventing cleavage by activated protein C)
- Prothrombin 20210 mutation (6%)
- Antithrombin deficiency (5%)
- Protein C deficiency (5%) (inactivates Va, VIIIa)
- Protein S deficiency (5%) (Protein C cofactor)
- hyperhomocysteinemia
- antiphospholipid antibodies (5%) (usually acquired)
- elevated factor VIII
Acquired
- Malignancy
- CVC
- Surgery, especially orthopedic
- Trauma
- Pregnancy
- Oral contraceptives
- Immobilization
- Congestive failure
- Antiphospholipid antibody syndrome
- Myeloproliferative disorders
- Polycythemia vera
- Essential thrombocythemia
- Paroxysmal nocturnal hemoglobinuria
- Inflammatory bowel disease
- Nephrotic syndrome