Trimethoprim/Sulfamethoxazole
aka Bactrim, Septrin, Resprim, Cotrimoxazole
Antibacterials
Other antibacterials
Contraindication <2mo (kernicterus)
Precautions Renal impairment (adjust if GFR <50ml/min)
Monitor FBE/K/Folate in high dose/long term use
Indications (trimethoprim dose)
Prophylaxis:
- UTI prophylaxis: 2mg/kg/dose PO nocte (max 80mg)
- Pneumocystis jirovecii pneumonia prophylaxis: 5mg/kg/dose PO daily MWF (max 320mg)
Infection:
- Standard: 4mg/kg/dose PO 12 hourly (max 320mg)
- Severe infection: 5mg/kg/dose IV 12 hourly (max 320mg)
- Pneumocystis pneumonia: 5mg/kg/dose PO/IV 6 hourly (max 320mg)
NB treats bacteria and fungi! (PCP)
Antibacterials
Other antibacterials
Contraindication <2mo (kernicterus)
Precautions Renal impairment (adjust if GFR <50ml/min)
Monitor FBE/K/Folate in high dose/long term use
Indications (trimethoprim dose)
Prophylaxis:
- UTI prophylaxis: 2mg/kg/dose PO nocte (max 80mg)
- Pneumocystis jirovecii pneumonia prophylaxis: 5mg/kg/dose PO daily MWF (max 320mg)
Infection:
- Standard: 4mg/kg/dose PO 12 hourly (max 320mg)
- Severe infection: 5mg/kg/dose IV 12 hourly (max 320mg)
- Pneumocystis pneumonia: 5mg/kg/dose PO/IV 6 hourly (max 320mg)
NB treats bacteria and fungi! (PCP)