Serology
An antigen can have many epitopes (i.e. many keys on a chain)
An antibody recognises a particular epitope
surface antigen = a protein on the surface of an infection = infectious
surface antibody = current/past infection/immunisation
core antibody = current/past infection (can't get from immunisation)
IgM = first antibody produced (by plasma cells) = acute infection in past 6 months, can also occasionally reactivate with reinfection
IgG = memory (previous infect/imm)
- IgG avidity increases with time making it helpful in differentiating recent and past infection if IgM is also positive
IgA1/2 = secreted, attaches antigen to epithelium
IgE
IgMADGE
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IgM -, IgG - = no previous exposure, susceptible (seroconversion is change from this to +)
IgM +, IgG - = recent infection
IgM +, IgG+ = ?reactivation ?reinfection > do IgG avidity, if high = past infection , otherwise treat as recent
IgM -, IgG + = past infection/immunisation = immune
CMV
Globulins : albumin, A1, A2, B, Gamma (Ig)
An antibody recognises a particular epitope
surface antigen = a protein on the surface of an infection = infectious
surface antibody = current/past infection/immunisation
core antibody = current/past infection (can't get from immunisation)
IgM = first antibody produced (by plasma cells) = acute infection in past 6 months, can also occasionally reactivate with reinfection
IgG = memory (previous infect/imm)
- IgG avidity increases with time making it helpful in differentiating recent and past infection if IgM is also positive
IgA1/2 = secreted, attaches antigen to epithelium
IgE
IgMADGE
------
IgM -, IgG - = no previous exposure, susceptible (seroconversion is change from this to +)
IgM +, IgG - = recent infection
IgM +, IgG+ = ?reactivation ?reinfection > do IgG avidity, if high = past infection , otherwise treat as recent
IgM -, IgG + = past infection/immunisation = immune
CMV
Globulins : albumin, A1, A2, B, Gamma (Ig)