Clotting
Common Pathway starts at Xa
PT check common path (II, V, X, I)
INR is a standardised Prothrombin Time (warfarin)
Coag tests tickle the top of the pathway and see if the bottom is effected
APTT XII-I (activated/intrinsic and common)
INR VII-I (TF/extrinsic and common)
ie
Isolated APTT = VIII, IX, XI or XII (addition of normal plasma aka mixing studies normalises XI, XII def i.e. if still prolonged its VIII, IX)
Both APTT and INR = X, V, II or I def
Isolated INR = VII
Both normal: normal or XIII def.
FFP has all
Cryo: VIII, Fibrinogen, vWF, XIII, fibronectin
Cryodepleted plasma (250-600ml): the rest
AntiXa monitors low-molecular weight heparin (clexane)
Warfarin is Vit K antagonist, inhibiting production of II, VII, IX, X as well as protein C and S
APTT checks intrinsic and common (used for heparin)
I = Fibrinogen
II = Prothrombin
III = Tissue factor
V leiden = mutant form that cannot be switched off by ProtC = thrombotic
PT check common path (II, V, X, I)
INR is a standardised Prothrombin Time (warfarin)
Coag tests tickle the top of the pathway and see if the bottom is effected
APTT XII-I (activated/intrinsic and common)
INR VII-I (TF/extrinsic and common)
ie
Isolated APTT = VIII, IX, XI or XII (addition of normal plasma aka mixing studies normalises XI, XII def i.e. if still prolonged its VIII, IX)
Both APTT and INR = X, V, II or I def
Isolated INR = VII
Both normal: normal or XIII def.
FFP has all
Cryo: VIII, Fibrinogen, vWF, XIII, fibronectin
Cryodepleted plasma (250-600ml): the rest
AntiXa monitors low-molecular weight heparin (clexane)
Warfarin is Vit K antagonist, inhibiting production of II, VII, IX, X as well as protein C and S
APTT checks intrinsic and common (used for heparin)
I = Fibrinogen
II = Prothrombin
III = Tissue factor
V leiden = mutant form that cannot be switched off by ProtC = thrombotic