Haematology Dx
Embryology
Anatomy
Physiology
Hx
Ex
Ix: Film, Bone marrow aspirate / trephine, cytogenetics
Blood forming tissues
Reticuloendothelial system
Haemoglobin
- Reticulocytes
- Hb electrophoresis
Haemopoesis
- Haemotinics (Fe, B12, Folate)
- Erythropoetin (incl Rx)
Anaemia
Aplastic (anaemia and reticulocytopenia)
Polycythemia
(WC see also immunology)
Neutropenia
Lymphocyto
Splenic disorders
Bleeding disorders
Thrombocytopenia
Coagulation
Haemophilia
Thrombophilia screen
Anticoagulants
Thrombolysis
Pancytopenia
Aplastic anaemia/bone marrow failure (ie with with hypocellular marrow)
Transfusion
Marrow transplant
Anatomy
Physiology
Hx
Ex
Ix: Film, Bone marrow aspirate / trephine, cytogenetics
Blood forming tissues
Reticuloendothelial system
Haemoglobin
- Reticulocytes
- Hb electrophoresis
Haemopoesis
- Haemotinics (Fe, B12, Folate)
- Erythropoetin (incl Rx)
Anaemia
Aplastic (anaemia and reticulocytopenia)
- Diamond-Blackfan anemia: craniofacial, thumb anomalies (so does fanconi)
Polycythemia
(WC see also immunology)
Neutropenia
- Shwachman-Diamond syndrome can have pancytopenia see below
Lymphocyto
Splenic disorders
- Howell-jolly bodies
- Encapsulated organisms
Bleeding disorders
Thrombocytopenia
- Wiskott-Aldrich syndrome (with eczema and thrombocytopenia)
Coagulation
Haemophilia
Thrombophilia screen
Anticoagulants
Thrombolysis
Pancytopenia
Aplastic anaemia/bone marrow failure (ie with with hypocellular marrow)
- Fanconi anaemia (short stature, thumb/radius anomaly, café-au-lait skin lesions, malignancy, VACTERL-H)
- Shwachman-Diamond syndrome usually neutropenia first (with pancreatic exocrine failure, and short stature)
- Dyskeratosis congenita: axial hyperpigmentation, nail dystrophy, mucosal leukoplakia...
- Amegakaryocytic thrombocytopenia: starts with low plt > develops AA, nothing else on presentation
Transfusion
Marrow transplant