Metformin
Treatment of T2DM
Class: Biguanide
Slow release improved compliance
Dose 500mg daily with dinner, increase every 2 weeks to max 2g
Side Effects:
Lactic acidosis
Abdo pain, diarrhoea, bloating
Regulates menstruation, Increasing fertility
Reduces acne
B12 deficiency
Use contraception
Monitor B12
Metformin (Reduces hepatic glucose production; increases peripheral utilisation of glucose)
Other classes:
Sulfonylureas (increase insulin secretion)
Thiazolidinediones (Increase the sensitivity of peripheral tissues to insulin; decrease hepatic glucose output)