Corynebacterium Diphtheria
Diphtheria
Gr+ rod
non-sporing
non-capsulate
spread by aerosol or direct contact with lesion
incubation 2-5 days
infective for 4 weeks
produces an endotoxin which acts locally on respiratory tract/skin producing a grey/green pseudomembrane
fatality 15%
Pharyngeal
Laryngeal
Cutaneous
Tracheitis
conjunctivitis
myocarditis
polyneuritis
adrenals
Prevention:
Vaccination DTPa (child formulation) dTpa (adult = lower doses of dip/pert)
(i.e. Infantrix/hexa v Boostrix)
6w, 4m, 6m, 18m, 4y, y7, 50y, 65y,
within 5y of travel to developing nations
Treatment
PPI inc resp precautions
Isolation
Antitoxin
Antibiotics
Notification
Gr+ rod
non-sporing
non-capsulate
spread by aerosol or direct contact with lesion
incubation 2-5 days
infective for 4 weeks
produces an endotoxin which acts locally on respiratory tract/skin producing a grey/green pseudomembrane
fatality 15%
Pharyngeal
Laryngeal
Cutaneous
Tracheitis
conjunctivitis
myocarditis
polyneuritis
adrenals
Prevention:
Vaccination DTPa (child formulation) dTpa (adult = lower doses of dip/pert)
(i.e. Infantrix/hexa v Boostrix)
6w, 4m, 6m, 18m, 4y, y7, 50y, 65y,
within 5y of travel to developing nations
Treatment
PPI inc resp precautions
Isolation
Antitoxin
Antibiotics
Notification