Neurology DX
Neuro Ex
Neuro toxin
Organophosphate poisoning / Sarin Chemical weapons (AChE)
Motor Neuron Disease
Upper
Mixed
Lower
Diagnoses (bold = Clinical Ex Cases)
Neuro toxin
Organophosphate poisoning / Sarin Chemical weapons (AChE)
Motor Neuron Disease
Upper
- pseudo bulbar palsy
Mixed
- ALS
Lower
- Bulbar palsy
Diagnoses (bold = Clinical Ex Cases)
- seizure disorder including febrile seizures and epilepsy
- meningitis, encephalitis
- cerebral palsy
- headache
- abnormal head size or shape
- CNS tumours (Link to oncology)
- cerebellar disorders (ataxia, hypoplasia)
- spinal cord disorders
- Transverse myelitis
- Neuromuscular diseases (which on these 4 are included in LMN) (weakness)
- Anterior horn cell
- Spinal Muscular Atrophy (1-4)
- Enterovirus (71, polio)
- Nerve
- Nerve root (radiculopathy): ventral (motor), dorsal (sensation)
- Plexus
- Brachial plexus injury
- Nerve (Neuropathy)
- neuropathies acquired and hereditary
- Hereditary motor sensory neuropathy
- Charcot-Marie-Tooth (demyelination)
- Guillain-Barré (axon or demyelination)
- Chronic inflammatory demyelinating polyneuropathy
- Acute intermittent porphyria
- Hereditary motor sensory neuropathy
- neuropathies acquired and hereditary
- NMJ (fatiguability)
- Botulism
- Myasthenia gravis (transient (maternal), congenital (genetic)...
- Magnesium toxicity
- Aminoglycoside toxicity
- Muscular (See myopathy table below)
- Muscular Dystrophy (dystrophin)
- Duchenne
- Becker
- Myotonic dystrophy (DM1: triplet repeat, severe, DM2:milder)
- Other myopathies
- Congenital
- Nemaline rod
- Central Core
- Metabolic
- McArdles (glycogen storage)
- Acid alpha-glucosidase deficiency (aka GAA / acid maltase / Pompe)
- characterised by dilated cardiomyopathy at birth
- Zellweger (cerebrohepatorenal syndrome)
- Electrolyte
- Infective
- Rhabdo
- Malignant hyperthermia
- Inflammatory
- Dermatomyositis
- Overlap syndromes (SLE..)
- Congenital
- Muscular Dystrophy (dystrophin)
- Anterior horn cell
- degenerative disorders
- ?Prion Diseases here
- ?CNS demyelination own chapter
- MS
- Leukodystrophy
- inherited and acquired encephalopathies, including neuronal storage disorders
- Neurocutaneous Syndromes
- tuberous sclerosis
- neurofibromatosis
- congenital brain abnormalities
- abnormalities of movement, e.g. tics, chorea, (?basal nuclei)
- Chorioathetosis
- dystonia
- hydrocephalus and raised intracranial pressure
- hemihypertrophy
- Wilms (Beckwith-Wiedemann)
- Cranial Nerve
- Möbius syndrome (Congenital facial nerve palsy CN VII (100%), CVI palsy (75%) eye abduction, other III>XIII rarely VIII usually spared
- CN Motor palsies
- Ophthalmoplegia (IIII, IV, VI)
- (?Masseter plegia V)
- Facial Palsy (VIII)
- Bulbar palsy (IX>XII)