Neutropenia
Haematology
Acquired
Congenital
Myeloperoxidase deficiency
Acquired
- Postinfectious neutropenia
- Bacterial (Rickettsial)
- Parasitic
- Viral - eg, hepatitis B, Epstein-Barr virus, HIV, HCV
- Drug-induced neutropenia and agranulocytosis (Clozapine, Thionamides, Sulfasalazine)
- Nutritional neutropenia
- Alcoholism
- B12/folate deficiency
- Copper deficiency
- Primary immune disorders
- Autoimmune
- Benign of childhood and adult chronic form
- Large granular lymphocyte syndrome
- Thymoma
- Isoimmune
- Autoimmune
- Complement activation (Hemodialysis, Filtration leukapheresis, Acute respiratory distress syndrome)
- Hypersplenism
- Transfusion reaction
- Chronic idiopathic
- Bone marrow disorders (usually pancytopenia)
- Leukaemia
- Aplastic Anaemia
- Chemotherapy marrow suppression
Congenital
- Severe congenital neutropenia (Kostman's syndrome)
- severe infantile agranulocytosis
- myelokathexis/neutropenia with tetraploid leukocytes
- Shwachman-Diamond-Oski syndrome (progresses to pancytopenia)
- Cyclic neutropenia
- Chediak-Higashi syndrome
- Reticular dysgenesis
- Dyskeratosis congenita
Myeloperoxidase deficiency
- myeloperoxidase used to identify neutrophils, if deficient > falsely low neutrophil count ie not neutropenic
- immunocomprimised